Placental expression of D6 decoy receptor in preeclampsia
نویسندگان
چکیده
منابع مشابه
Placental expression of D6 decoy receptor in preeclampsia
OBJECTIVE The purpose of this study was to investigate the expression of the D6 decoy receptor that can bind chemokines and target them for degradation, resulting in inhibition of inflammation in placentas from preeclamptic and normal pregnancies. METHODS The current study was carried out in 35 pregnant women (23 patients with preeclampsia and 12 healthy, normotensive pregnant women) during t...
متن کاملHemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1.
D6 scavenges inflammatory chemokines and is essential for the regulation of inflammatory and immune responses. Mechanisms explaining the cellular basis for D6 function have been based on D6 expression by lymphatic endothelial cells. In this study, we demonstrate that functional D6 is also expressed by murine and human hemopoietic cells and that this expression can be regulated by pro- and anti-...
متن کاملExpression of the chemokine decoy receptor D6 mediates dendritic cell function and promotes corneal allograft rejection
PURPOSE To identify the role of chemokine receptor 6 (D6) expression by dendritic cells (DCs) and its role in corneal transplant immunity. METHODS Flow cytometry analysis was used to assess the expression level of the D6 chemokine receptor in different leukocyte populations and DC maturation following lipopolysaccharides (LPS) stimulation of bone marrow-derived DCs isolated from wild-type (WT...
متن کاملPlacental Chemokine Receptor D6 Is Functionally Impaired in Pre-Eclampsia
BACKGROUND Pre-eclampsia (PE) is a major cause of maternal and perinatal morbidity and mortality worldwide. It is defined by new onset of hypertension and proteinuria after the 20th week of gestation and characterized by systemic exaggerated inflammatory response. D6 is a chemokines scavenger receptor that binds with high affinity CC chemokines, internalizes and targets the ligands for degradat...
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http://gut.bmj.com/content/59/2/151.full.html Updated information and services can be found at: These include: References http://gut.bmj.com/content/59/2/151.full.html#ref-list-1 This article cites 10 articles, 2 of which can be accessed free at: service Email alerting right corner of the online article. Receive free email alerts when new articles cite this article. Sign up in the box at the to...
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ژورنال
عنوان ژورنال: Obstetrics & Gynecology Science
سال: 2015
ISSN: 2287-8572,2287-8580
DOI: 10.5468/ogs.2015.58.5.333